个人简介
| 男，汉族。2018年毕业于四川大学华西药学院药物化学专业。硕士博士期间主要从事不对称有机催化研究及手性药物中间体制备。目前研究方向为创新医药中间体的高效合成及不对称催化合成方法学，参与多项国家自然基金面上项目，同时作为项目负责人主持国家自然科学基金青年基金项目和四川省自然基金项目。并在该领域以第一作者或通讯作者在国际主流化学期刊，如ACS Catalysis, Organic Letters, Chemistry-A European Journal, Organic Chemistry Frontiers , ChemCatChem等发表多篇文章。 |
工作经历
| 2018.12-至今，伟德bv1946官网制药工程系2018.07-2018.11，成都先导药物开发有限公司 |
教育经历
| 2008.09-2012.06，山西医科大学药学院药学专业，本科2012.09-2018.07，四川大学华西药学院药物化学专业，博士，导师：陈应春 |
研究方向
1.创新医药中间体的合成与发现 2.不对称催化合成 |
学术成果
1. Yan-Li Li , Zhi-Ming Li , Kai-Kai Wang , Xiao-Long He,* Beyond 1,4-addition of in-situ generated (aza-) quinone methides and 2. Kai-Kai Wang, Yan-Li Li, Ya-Fei Li, Wei-Wei Yao, Lan-Xin Li, Xiao-Long He,* Rongxiang Chen,* Substrate-controlled [4+1] and [3+2] annulations of ninhydrin-derived Morita–Baylis–Hillman carbonates to access polysubstituted furans and cyclopentenes, Chem. Commun., 2024,60, 3717-3720. (JCR Q2, 4.9) 3. Xiao-Long He, You-Wu Wen, Hechen Li, Shan Qian,* Mengyang He, Qiao Song, and Zhouyu Wang*, Diastereoselective Synthesis of Dihydrobenzofuran-Fused Spiroindolizidines via Double-Dearomative [3 + 2] Cycloadditions, J. Org. Chem. 2023, 88, 493-503. (JCR Q2, 4.198) 4. Yan-Li Li, Kai-Kai Wang and Xiao-Long He*, Recent Progress of Electron-Withdrawing-Group-Tethered Arenes Involved Asymmetric Nucleophilic Aromatic Functionalizations, Adv. Synth. Catal.2022, 364, 3630–3650. (JCR Q2, 5.981 ). 5. Zongyuan Luo , Zhangyan Zhu , Tingrui Zhang, Hu Jiang, Nan Huang, Feng Liang, Zhouyu Wang , Yuzhi Li, Xiao-Long He, Shan Qian, A lysosome-targeting fluorescent probe to visualize endogenous and exogenous methylglyoxal in live cells and zebrafish, Analyst, 2022, 147, 4949-4953. (JCR Q2, 5.227 ). 6. Xiao-Long He, Cheng Wang, You-Wu Wen, Yi-Bing Zhao, Huan Yang, Shan Qian, Lingling Yang* and Zhouyu Wang*, Highly stereoselective dearomative [3 + 2] cycloadditon of cyclic pyridinium ylides to access spiro-indolizidine scaffolds, Org. Chem. Front., 2021, 8, 5847-5851. （JCR Q1, IF 5.28） 7.Xiao-Long He, Cheng Wang, You-Wu Wen, Zhouyu Wang*, and Shan Qian*, Recent Advances in Catalytic Atroposelective Construction of Pentatomic Heterobiaryl Scaffolds, ChemCatChem, 2021, DOI: 10.1002/cctc.202100539. （JCR Q2, IF 5.69） 8. Xiao-Long He, Hui-Ru Zhao, Xue Song, Bo Jiang, Wei Du*, and Ying-Chun Chen*, “Asymmetric Barton−Zard Reaction To Access 3‑Pyrrole-Containing Axially Chiral Skeletons”, ACS Catal. 2019, 9, 4374−4381. （JCR Q1, IF 13.08） 9. Xiao-Long He, Hui-Ru Zhao, Chuan-Qi Duan, Wei Du, and Ying-Chun Chen*, “Remote Asymmetric Oxa-Diels−Alder Reaction of 5‑Allylic Furfurals via Dearomatizative Tetraenamine Catalysis”, Org. Lett.2018, 20, 804–807. (JCR Q1, IF 6.00) 10. Xiao-Long He, Hui-Ru Zhao, Chuan-Qi Duan, Xu Han,Wei Du, and Ying-Chun Chen*, “Asymmetric Benzylic Allylic Alkylation Reaction of 3-Furfural Derivatives via Dearomatizative Dienamine Activation”, Chemistry-A European Journal, 2018, 24, 6277–6281. (JCR Q2, IF 5.24) 11. Xiao-Long He, You-Cai Xiao, Wei Du, and Ying-Chun Chen*, “Enantioselective Formal [3+3] Cycloadditions of Ketones and Cyclic 1-Azadienes by Cascade Enamine–Enamine Catalysis”, Chemistry-A European Journal2015, 21, 3443–3447. (JCR Q2, IF 5.24) 10. Chuan-Qi Duan, Xiao-Long He, Wei Du, and Ying-Chun Chen*, Asymmetric [4 + 2] cycloadditions with 3-furfural derivatives and α-cyano-α,β-unsaturated ketones, Org. Chem. Front., 2018, 5, 2057–2060. (JCR Q1, IF 5.28) 12. Qian-Qian Yang, Xiang Yin, Xiao-Long He, Wei Du*, and Ying-Chun Chen*, Asymmetric Formal [5 + 3] Cycloadditions with Unmodified Morita–Baylis–Hillman Alcohols via Double Activation Catalysis, ACS Catal. 2019, 9, 1258–1263. （JCR Q1, IF 13.08） 13. Chang-Jiang Xu, Hong-Wei Li, Xiao-Long He, Wei Du*, Ying-Chun Chen*, Asymmetric Direct Remote Michael Addition Reactions of Allyl Furfurals via Dearomative Trienamine and Tetraenamine Catalysis, Asian J. Org. Chem.2019, 8, 1037–1040. (JCR Q3, IF 3.32) |
教学工作
入校以来主要承担药物合成反应,制药工艺学等课程的教学工作；同时，做为研究生导师开展创新课题的研究以及学科竞赛的指导工作 |